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Home > Polyphenols > Proanthocyanidins

Indexed by NutrientIndex One of the research focus areas of ALH Nutritional Research is polyphenols, including proanthocyanidins. The following articles describe research regarding proanthocyanidins. Some of the scientific publications below are provided for free, while others are only available if you have a journal subscription. You may want to consult the symbol legend.

Why are these articles indexed?
These publications are indexed through our NutrientIndexTM program, because their topics are considered suitable for scientific review in the near future or have already been reviewed by ALH Nutritional Research.

Cardiovascular Research
   Animal research (6)
   In-vitro/ex-vivo research (13) 		Analytical Chemistry (2)
Cancer Research
   In-vitro/ex-vivo research (3)

  Cardiovascular Research
Animal research
Cardioprotective roles of aged garlic extract, grape seed proanthocyanidin, and hazelnut on doxorubicin-induced cardiotoxicity.
Demirkaya E, Avci A, Kesik V et al. Can J Physiol Pharmacol. 2009 Aug;87(8):633-40. Indexed by PubMed, Image License: Public Domain   Indexed by Google Scholar, Image License: Public Domain
Protective effect of grape seed proanthocyanidin extract against oxidative stress induced by cisplatin in rats.
Yousef MI, Saad AA, El-Shennawy LK. Food Chem Toxicol. 2009 Jun;47(6):1176-1183. Indexed by PubMed, Image License: Public Domain   Indexed by Google Scholar, Image License: Public Domain
Amelioration of doxorubicin-induced myocardial oxidative stress and immunosuppression by grape seed proanthocyanidins in tumour-bearing mice.
Zhang XY, Li WG, Wu YJ et al. J Pharm Pharmacol. 2005 Aug;57(8):1043-52. Indexed by PubMed, Image License: Public Domain   Indexed by Google Scholar, Image License: Public Domain
Acute and long-term safety evaluation of a novel IH636 grape seed proanthocyanidin extract.
Ray S, Bagchi D, Lim PM et al. Res Commun Mol Pathol Pharmacol. 2001 Mar-Apr;109(3-4):165-97. Indexed by PubMed, Image License: Public Domain   Indexed by Google Scholar, Image License: Public Domain
In vivo protection of dna damage associated apoptotic and necrotic cell deaths during acetaminophen-induced nephrotoxicity, amiodarone-induced lung toxicity and doxorubicin-induced cardiotoxicity by a novel IH636 grape seed proanthocyanidin extract.
Ray SD, Patel D, Wong V et al. Res Commun Mol Pathol Pharmacol. 2000;107(1-2):137-66. Indexed by PubMed, Image License: Public Domain   Indexed by Google Scholar, Image License: Public Domain
Cardioprotective effects of grape seed proanthocyanidin against ischemic reperfusion injury.
Sato M, Maulik G, Ray PS et al. J Mol Cell Cardiol. 1999 Jun;31(6):1289-97. Indexed by PubMed, Image License: Public Domain   Indexed by Google Scholar, Image License: Public Domain

In-vitro/ex-vivo research
Grape seed proanthocyanidins protect cardiomyocytes from ischemia and reperfusion injury via Akt-NOS signaling.
Shao ZH, Wojcik KR, Dossumbekova A et al. J Cell Biochem. 2009 Jul 1;107(4):697-705. Indexed by PubMed, Image License: Public Domain   Indexed by Google Scholar, Image License: Public Domain
Catechin and proanthocyanidin B4 from grape seeds prevent doxorubicin-induced toxicity in cardiomyocytes.
Du Y, Lou H. Eur J Pharmacol. 2008 Sep 4;591(1-3):96-101. Indexed by PubMed, Image License: Public Domain   Indexed by Google Scholar, Image License: Public Domain
Mechanisms underlying the vasorelaxant effect induced by proanthocyanidin-rich fraction from Croton celtidifolius in rat small resistance arteries.
DalBó S, Moreira EG, Brandão FC et al. J Pharmacol Sci. 2008 Feb;106(2):234-41. Indexed by PubMed, Image License: Public Domain   Indexed by Google Scholar, Image License: Public Domain   Free Article
Grape seed polyphenols protect cardiac cells from apoptosis via induction of endogenous antioxidant enzymes.
Du Y, Guo H, Lou H. J Agric Food Chem. 2007 Mar 7;55(5):1695-701. Indexed by PubMed, Image License: Public Domain   Indexed by Google Scholar, Image License: Public Domain
Cardioprotective mechanisms of Prunus cerasus (sour cherry) seed extract against ischemia-reperfusion-induced damage in isolated rat hearts.
Bak I, Lekli I, Juhasz B et al. Am J Physiol Heart Circ Physiol. 2006 Sep;291(3):H1329-36. Indexed by PubMed, Image License: Public Domain   Indexed by Google Scholar, Image License: Public Domain   Free Article
Cytotoxicity induced by grape seed proanthocyanidins: role of nitric oxide.
Shao ZH, Hsu CW, Chang WT et al. Cell Biol Toxicol. 2006 May;22(3):149-58. Indexed by PubMed, Image License: Public Domain   Indexed by Google Scholar, Image License: Public Domain
Grape seed proanthocyanidins induce pro-oxidant toxicity in cardiomyocytes.
Shao ZH, Vanden Hoek TL, Xie J et al. Cardiovasc Toxicol. 2003;3(4):331-9. Indexed by PubMed, Image License: Public Domain   Indexed by Google Scholar, Image License: Public Domain
Grape seed proanthocyanidin extract attenuates oxidant injury in cardiomyocytes.
Shao ZH, Becker LB, Vanden Hoek TL et al. Pharmacol Res. 2003 Jun;47(6):463-9. Indexed by PubMed, Image License: Public Domain   Indexed by Google Scholar, Image License: Public Domain
Proanthocyanidin: a natural crosslinking reagent for stabilizing collagen matrices.
Han B, Jaurequi J, Tang BW et al. J Biomed Mater Res A. 2003 Apr 1;65(1):118-24. Indexed by PubMed, Image License: Public Domain   Indexed by Google Scholar, Image License: Public Domain
Mechanistic pathways of antioxidant cytoprotection by a novel IH636 grape seed proanthocyanidin extract.
Bagchi D, Ray SD, Bagchi M et al. Indian J Exp Biol. 2002 Jun;40(6):717-26. Indexed by PubMed, Image License: Public Domain   Indexed by Google Scholar, Image License: Public Domain
Anti-angiogenic property of edible berries.
Roy S, Khanna S, Alessio HM et al. Free Radic Res. 2002 Sep;36(9):1023-31. Indexed by PubMed, Image License: Public Domain   Indexed by Google Scholar, Image License: Public Domain
Grape seed proanthocyanidins improved cardiac recovery during reperfusion after ischemia in isolated rat hearts.
Pataki T, Bak I, Kovacs P et al. Am J Clin Nutr. 2002 May;75(5):894-9. Indexed by PubMed, Image License: Public Domain   Indexed by Google Scholar, Image License: Public Domain   Free Article
Grape seed proanthocyanidin reduces cardiomyocyte apoptosis by inhibiting ischemia/reperfusion-induced activation of JNK-1 and C-JUN.
Sato M, Bagchi D, Tosaki A et al. Free Radic Biol Med. 2001 Sep 15;31(6):729-37. Indexed by PubMed, Image License: Public Domain   Indexed by Google Scholar, Image License: Public Domain
 
  Analytical Chemistry
Assessment of the polyphenolic composition of the organic extracts of Mauritian black teas: a potential contributor to their antioxidant functions.
Luximon-Ramma A, Neergheen VS, Bahorun T et al. Biofactors. 2006;27(1-4):79-91. Indexed by PubMed, Image License: Public Domain   Indexed by Google Scholar, Image License: Public Domain
Anti-angiogenic property of edible berries.
Roy S, Khanna S, Alessio HM et al. Free Radic Res. 2002 Sep;36(9):1023-31. Indexed by PubMed, Image License: Public Domain   Indexed by Google Scholar, Image License: Public Domain
 
  Cancer Research
In-vitro/ex-vivo research
NFkappaB-dependent regulation of urokinase plasminogen activator by proanthocyanidin-rich grape seed extract: effect on invasion by prostate cancer cells.
Uchino R, Madhyastha R, Madhyastha H et al. Blood Coagul Fibrinolysis. 2010 May 24. Indexed by PubMed, Image License: Public Domain   Indexed by Google Scholar, Image License: Public Domain
Grape seed proanthocyanidin suppression of breast cell carcinogenesis induced by chronic exposure to combined 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and benzo[a]pyrene.
Song X, Siriwardhana N, Rathore K et al. Mol Carcinog. 2010 May;49(5):450-63. Indexed by PubMed, Image License: Public Domain   Indexed by Google Scholar, Image License: Public Domain
Chemical analysis and screening as anticancer agent of anthocyanin-rich extract from Uva Caimarona ( Pourouma cecropiifolia Mart.) fruit.
Barrios J, Cordero CP, Aristizabal F et al. J Agric Food Chem. 2010 Feb 24;58(4):2100-10. Indexed by PubMed, Image License: Public Domain   Indexed by Google Scholar, Image License: Public Domain

Record history: June 21, 2010

ALH Nutritional Research is part of ALH Nutrition, Staalstraat 29c, 3572 RG, Utrecht, The Netherlands - research@alhnutrition.nl